Mercedes-Benz S-Class Sedan

Starting MSRP: $85,750
Five-year cost of ownership: $171,130

Like the two Mercedes models that fall before it on this list, the S-Class expenses run high because its ultra-high performing AMG version elevates the average cost of ownership for the entire car line. Considered alone, the S65 AMG Sedan duns its owners for an astonishing $243,491 over five years. If you took it out of the mix, the other three S-Class versions sold by Mercedes — the S550, S550 with 4Matic all-wheel drive and S600 — would cost owners an average of $147,010 after five years.